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KMID : 0882420100790020113
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Korean Journal of Medicine
2010 Volume.79 No. 2 p.113 ~ p.118
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Understanding of molecular pathogenesis and genetic markers in colorectal cancer
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Kim Young-Ho
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Abstract
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Colorectal cancers results from the progressive accumulation of genetic and epigenetic alterations that lead to cellular transformation and tumor progression. Genomic instability, including chromosomal translocations and microsatellite instability, plays a role in acquisition of enough mutations for malignant transformation. In addition, epigenetic silencing is an important mechanism in the evolution of a subgroup of colorectal cancers. These genetic and epigenetic changes causes activation of oncogene pathway (APC, KRAS) and inactivation of tumor-suppressor pathway (p53, TGF-β). Recent advance in colorectal carcinogenensis leads to development of molecular markers for early detection and predictive and prognostic markers.
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KEYWORD
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Colorectal cancer, Genetic instability, Epigenetic change, Biomarker
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